Computational Biology

The future of DNA sequencing is already in the classroom

In Ubiquitous Genomics, students are among the first students to have access to a mobile genetic sequencer.

Genome-wide association studies, minus the Winner’s Curse, are shown to be reliable and replicable

Columbia researchers de-bias the effects of the Winner’s Curse across a broad set of traits, finding that reporting deficiencies, not the paradigm of GWAS, are to blame for the failure to replicate.

DNA.Land

A website for crowd-sourcing human genome data for research purposes.

About

Computational biology and bioinformatics involve development and application of analysis methods for high throughput experimental data in molecular biology to facilitate biomedical research. Active topics of investigation in Columbia involve systems biology, biological networks, massively parallel (“next generation”) DNA sequencing, RNA sequencing, ChIP sequencing, analysis of transcription factor binding sites, single nucleotide polymorphisms, population genetics, molecular evolution, personalized medicine, tumor genomics.