MutaGeneSys uses genome-wide genotype data to estimate individual disease susceptibility. Our system integrates three data sources: the International HapMap project(hapmap.org), whole-genome marker correlation data (description) and the Online Mendelian Inheritance in Man database (OMIM). MutaGeneSys accepts SNP data of individuals as query input and delivers disease susceptibility hypotheses even if the original set of typed SNPs is incomplete. Our system produces population, genotyping technology, and confidence-specific predictions in interactive time.
There are several ways to use MutaGeneSys:
* Access it through a web interface (scheduled for release on October 18th, 2007).
* Install the complete system on your own machine (installation information).
* A sub-set of our findings has been incorporated into HapMap GBrowse and James Watson's Personal Genome Sequence browser. Example of a region with multiple OMIM associations: Chr1:194923128..194933127 (check the OMIM_Associations track). James Watson's browser is accessible here.
* You may also download a complete set of our findings in comma-separated format (scheduled for release on October 18th, 2007).
MutaGeneSys is available for use free of charge. If you use our system for scientific research that results in a publication, please cite our most recent publication (see here).