Current Research Interests

Machine learning

• Large margin generative probabilistic models
• Transductive and semi-supervised learning
• Nearest Neighbor classifiers
• Approximate Bayes optimal linear classifiers
• Bayes point machines

Computational Biology

• Protein-protein interaction prediction
• Protein function prediction
• Micro-array gene expression analysis

Current Results

• MED for Gaussian mixtures
• Internal

Previous Research

• Physics of Computation

Papers

• Darrin P. Lewis, Tony Jebara, and William Stafford Noble. "Support vector machine learning from heterogeneous data: an empirical analysis using protein sequence and structure." Bioinformatics (accepted).
• Darrin P. Lewis, Tony Jebara, and William Stafford Noble. "Nonstationary Kernel Combination." Proceedings of the International Conference on Machine Learning, June 25-29, 2006, Pittsburgh, PA.
• Darrin P. Lewis and William Stafford Noble. "Large Margin Prediction of Protein-Protein Interactions." NIPS 2003 Workshop on New Methods in Bioinformatics.
• Darrin P. Lewis and William Stafford Noble. "Regularized nearest neighbor." NIPS 2003 Workshop on Approximate Nearest Neighbor Techniques (Poster presentation).
• Qin, Jie, Darrin P. Lewis and William Stafford Noble. "Kernel hiearchical gene clustering from microarray expression data." Bioinformatics. 19(16):2097-2104, 2003.
• Pavlidis, Paul, Darrin P. Lewis and William Stafford Noble. "Exploring gene expression data with class scores." Proceedings of the Pacific Symposium on Biocomputing, January 2-7, 2002.
• C. Anastassiou, K. Steiglitz, D. Lewis, M. Segev, J. Giordmaine. "Bouncing of Vector Solitons." Conference on Lasers and Electro-Optics (CLEO) 2000, San Fransisco, May 7-12, 2000.
• D. Lewis, K. Steiglitz, M. Jakubowski, R. Squier. "State Change Operations for Manakov Soliton Collisions are Associative (But Not Commutative)." Physical Review E. (submitted)
• C. Sastry, D. Lewis, A. Pizano. "WebTour: A System to Record and Playback Dynamic Multimedia Annotations on Web Document Content." Proceedings of ACM Multimedia 99, Orlando, FL. 175-178.