Optimal design and Power Estimation for Rare variant Association (OPERA)
Distribution of depth coverage:
Poisson
Negative binomial
Custom table of power vs. depth coverage
Plot:
distribution of depth coverage
power to detect variant
minimum proportion of carriers vs. number of cases
minimum proportion of carriers in cases vs. total number of samples, sequencing both cases and controls
power vs. number of cases, given frequency of variant in cases
power vs. number of cases, given frequency of variant in controls and odds ratio
power vs. total number of samples, sequencing both cases and controls, given frequency of variant in cases
power vs. total number of samples, sequencing both cases and controls, given frequency of variant in controls and odds ratio
Average depth-coverage:
Plot:
X axis: from
to
step
Y axis: from
to